Our spectrometer uses Cavity Ring-Down Spectroscopy (CRDS), which is superior to other methods of breath analysis. Picomole's breath spectrometer works by introducing a gas sample into an optical cavity that is then probed with a sequence of laser pulses. The optical cavity lengthens the interaction time of the sample with the laser pulse by a thousand-fold or more, dramatically increasing the sensitivity to trace compounds. One key advantage to CRDS is that it is a time based measurement, meaning that the lasers do not require calibration. Picomole is the only company in the world that makes use of CRDS technology for breath analysis, giving Picomole the most accurate breath analysis results in the field.
Picomole's breath spectrometer is both fast and powerful, permitting sample analysis down to parts-per-trillion levels and below within minutes. Picomole's breath spectrometer generates a fingerprint-like assessment, called a composite biomarker. The composite biomarker is amenable to analysis by machine learning software.
To best understand CRDS, consider the sound of a bell. The initial chime produces a loud ring whose volume gradually fades over time. This ringing-down effect is the dominant principle behind CRDS. Laser light is introduced to the ring-down chamber and
trapped between two mirrors. The light continuously reflects between the mirrors, with some escaping during each bounce. A chamber will "ring-down" the light in a precisely determined amount of time. When a sample is introduced to the chamber, this ring-down time becomes faster due to additional light being absorbed. This time-based approach affords CRDS a level of sensitivity beyond what is available to conventional IR techniques.
To discuss possible research opportunities with Picomole's CRDS breath spectrometer,